Optimize Cell Culture & Expansion
Overcome the challenges of cell culture, cell expansion and cell performance
Cell culture performance depends on the quality and consistency of the materials used to support cell growth, expansion, and function. Media supplements and recombinant proteins must deliver reproducible biological activity while meeting the quality requirements of increasingly advanced cell and gene therapy workflows. BioLife Solutions offers a growing portfolio of human platelet lysates (hPL), cytokines, and growth factors designed to support consistent cell performance from research through manufacturing.
Human Platelet Lysates
Our pathogen-reduced human platelet lysates (hPL) provide you with a media that reduces risks and improves downstream performance over Fetal Bovine Serum (FBS) and other chemically defined media. We provide a range of products and will suggest a solution for you, dependent on the regulatory and packaging needs of your processes. And with our robust supply, you’ll have a media that not only performs – but is available when you need it most.
Cell Performance
Solutions
Stemulate®-CP
Human Platelet Lysate (hPL)
Stemulate-CP is a xeno- and heparin-free pooled human platelet lysate that is used globally in clinical stem cell and immuno-oncology applications.
Details:
- Available in 100 mL and 500 mL sizes, manufactured from outdated FDA/AABB approved apheresis platelet units
- Manufactured under an ISO 9001:2015 Quality Management System
- Typically used at 2%-10% concentrations
- Large donor pool lot sizes
- FDA Master File
nLiven PR®
Human Platelet Lysate (hPL)
nLiven PR is a GMP-ready pathogen-reduced human platelet lysate with superior performance and quality standards that offers significant advantages for cell and gene therapy manufacturing by providing a reliable and effective culture supplement that improves cell growth, reduces contamination risks, enhances consistency, and can potentially lower manufacturing costs.
Details:
- Utilizes E-Beam irradiation for pathogen reduction, meeting EU Pharmacopoeia standards
- A Biodefined composition that reduces lot-to-lot variability compared to traditional PL preparations
- Contains high concentrations of growth factors and cytokines, promoting cell growth and proliferation
- Manufactured under a certified ISO 9001:2015 Quality Management System
- Manufactured in accordance with cGMP standards
- Manufactured from large donor pool lot sizes
- Available in 100 mL and 500 mL sizes
- Typically used at 2%-10% concentrations
- FDA Master File, Japan PMDA Certificate of Suitability
T-Liven PR®
Human Platelet Lysate (hPL)
T-Liven PR is a GMP-ready human platelet lysate for closed-system bioprocessing with release against a T cell growth release assay for optimal immune cell quality.
Details:
- GMP-Ready: Manufactured under a certified ISO 9001:2015 Quality Management System
- Validated pathogen-reduction technology using E-Beam irradiation
- Available in bag format
- Large donor pool lot sizes
- Manufactured from outdated FDA/AABB approved apheresis platelet units
- Used for manufacturing in US, EU, and other clinical trials globally
- Typically used at concentrations ranging from 2% to 10%
- Used in 2D and 3D expansion systems
- Pathogen reduction applied per EU Pharmacopoeia
- FDA Master File, Japan PMDA Certificate of Suitability
Integrated solutions to automate and close your workflow
BioLife Solutions portfolio of cell processing solutions optimizes and protects your cells while providing increased safety and flexibility for your manufacturing suite. Our tools are designed with the evolving nature of cell and gene therapy (CGT) manufacturing in mind as we work to help developers bring new and transformative therapies to market.
Processing &
Handling Solutions
Signata CT-5®
Automated aliquoting for high-value cell products
The Signata CT-5 is a compact, benchtop aliquoting system that enables automated, aseptic filling into vials (including CellSeal® Cryogenic Vials) without the need for a biosafety cabinet. With its intuitive touchscreen interface, pre-configured fill protocols, and compatibility with closed tubing sets, the Signata CT-5 minimizes operator intervention and enhances repeatability.
Key benefits:
- Reduces cleanroom footprint
- Enhances batch reproducibility
- Lowers operator time and error
CellSeal® Connect
Seamless, closed-system transfer
CellSeal Connect advances the CellSeal platform with weldable fill and retrieval and vent tubes. Designed for the closed-system introduction of intermediate reagents for activation, transduction, and expansion, these vials allow fill and retrieval in a closed manner via sterile welding onto downstream processing systems.
Applications:
- Mid-process sampling
- Drug product fill/finish
- Cryopreserved cell transfer
CellSeal® CryoCase
Redefining cryostorage standards
The CellSeal CryoCase is a rigid, cryopreservation container designed for CGT storage. It’s the first rigid container engineered for closed-system fill and retrieval of larger volumes of fluid (<75 mL). Its importance lies in addressing limitations of traditional cryobags, particularly the presence of particulates and the risk of leaks and fractures.
The CellSeal CryoCase has demonstrated:
- A reduction in particulates
- Improved inspectability
- Compatibility with closed-system processing
- Versatility with fill volumes
- Durability unseen before in primary container storage
Cytokines and growth factors
Expanding on our foundational CGT media component human platelet lysate (hPL) portfolio, BioLife Solutions now offers a growing family of enhanced quality recombinant proteins to support your cell therapy and organoid workflows.
Cytokines &
Growth Factors
IL-2
Support T-cell and NK-cell expansion and activation with highly pure, animal origin-free IL-2
Human interleukin-2 (IL-2) is a key cytokine that regulates immune responses by driving T-cell and NK-cell proliferation and differentiation. In a dose- and context-dependent manner, IL-2 enhances effector function while supporting regulatory T-cell (Treg) maintenance, enabling balanced immune activation and control.
IL-7
Support T-cell survival, homeostasis and maintenance with highly bioactive IL-7
Human interleukin-7 (IL-7) is essential for early lymphoid progenitor development and homeostasis. IL-7 supports the maintenance of naive and memory T-cell populations, making it a valuable cytokine for immunology research and regenerative medicine applications.
IL-15
Support NK-cell expansion and cytotoxic lymphocyte persistence with highly bioactive IL-15
IL-15 is a key cytokine that regulates immune responses by supporting the proliferation and persistence of cytotoxic lymphocytes. IL-15 promotes the expansion of NK cells and memory CD8+ T cells, supports T-cell survival, and influences myeloid differentiation, including dendritic cell maturation.
FGF-2
Support stem and progenitor cell maintenance, proliferation and expansion with highly pure FGF-2
FGF-2 is a key growth factor that regulates cell proliferation and survival. It supports the expansion and maintenance of stem and progenitor cells, including mesenchymal and pluripotent stem cells, making it widely used in stem cell culture and regenerative medicine applications.
